Christian and Sean struggle to rebuild their practice as they settle into their new location; a Hollywood publicist offers to help build Christian and Sean’s images through the media.

Sean and Christian learn about the glamorous side of fame and the price that many are willing to pay for it. Julia visits Sean, Christian and Liz in Lost Angeles with a surprise announcement.

Sean and Julia learn more about their family dynamics as Sean resists Eden’s advances; Kate reveals a secret compulsion; Matt comes to Los Angeles with some troubling news for his fathers.

A series of unfortunate events unfolds for unlucky Dawn Budge, who again requires the professional services of Sean and Christian. Meanwhile, the sisterly bond that Annie and Eden are forming unnerves Sean.

Sean is inspired by a patient to further his relationship with Kate. Eden goes to extremes to surgery performed on a friend by Christian. Kimber seeks help from a former business associate after she and Matt fall on hard times.

Christian, horning in on Sean’s newfound fame, convinces him to film a reality based show concerning their plastic surgery careers.

Sean uses his relationship with Eden to recapture his youth. Also, a violent and traumatic event makes Julia question her relationship with Olivia and Matt is devastated by Kimber’s decision.

A secret about Julia that Christian has keeping to himself is discovered by Sean. Matt forms a bond with his rehabilitation counselor at the hospital. Meanwhile, Eden’s peace agreement with Julia seems suspicious, while Kimber and Ram reveal their plans for the future.

Hearts ’n’ Scalpels producer Dawn Budge, refuses to allow the show to join a gay-pride parade. Meanwhile, Christian starts with his old habits again, and Sean hires Gina as a receptionist, to get back at Christian because of Julia. Also, Matt’s disfigured rehab counselor, Rachael Ben Natan, sees Sean when ever experiencing a face pain, but the case is more intense than it seems.

An older woman wants the effects of her younger husband’s electrolysis procedure undone by Sean and Christian. Meanwhile, a talent agent is hired by Sean; Christian wants to know why Gina is moving to Los Angeles; and Julia’s illness is still a mystery.

Christian attempts to move on in the wake of Gina’s death. Also, when another agency becomes interested in Sean’s career, Colleen feels her business is being threatened.

Sean helps out Eden when she joins Kimber and Ram in business. Christian is hired by a group of socialites to perform their cosmetic surgery wants, and Sean sees a different side of Colleen.

Sean is shown the ugly side of Hollywood from a TV critic, while Matt and one of Christine’s patients experience a close bond. Also, Julia finally gets an explanation of why she’s been ailing.

Julia discovers the cause of her poor health as tragedy strikes the McNamara-Troy family. Meanwhile, revealing news from Christians past is uncovered by a visitor, and Sean finds that fame comes with a price.

In the premiere episode for this second segment of season five, Sean's physical and emotional well-being is greatly impacted after he survives the attack from Colleen . Meanwhile, Christian gets some troubling news. Sean's physical and emotional well-being is greatly impacted after he survives the attack from Colleen (SHARON GLESS). Meanwhile, Christian gets some troubling news. Sean feels unstable after Colleen's (SHARON GLESS) attack

As Christian becomes more physically weak as he starts chemotherapy treatments, he eventually ends up calling out to Liz for emotional support after both Kimber and Julia reject him. Meanwhile, Raj develops an attraction to the trans-gender wife of a trans-gender male patient whom is being operated on for his lack of masculinity.

Candy Richards, the washed-up, narcissistic actress returns wanting Christian and Sean to perform a skin pigment implantation to make her more African-American for her re-discovered roots. Meanwhile, Christian meets a feisty, chain-smoking lady, named Roxy St. James, at a cancer victims therapy group where she wants him to perform a mastectomy on her to cure her incurable fear of developing breast cancer.

Sean's appreciation of Raj further strains his relationship with Matt. Christian returns to womanizing after his pectoral reconstruction, causing an irrevocable rift with Liz that has long-term ramifications for the future of McNamara/Troy. Raj's father, the esteemed doctor Vijay Paresh,wants his son to perform his penis enlargement surgery, but is disappointed to discover his lack of surgery skills.

Yoga coach approaches the surgeons to request an operation they have to invent: a penis reduction, because he's so limber and horny he can't resist giving himself a contortionist blow-job almost all day. Aidan Stone wants revenge for his career being wrecked by Sean taking over the led in his medical soap. An inappropriate picture may do the trick. Christian reluctantly looks into Kimber's demand to fix Matt's baby's 'eerily thin' lips for an infantile modeling career.

A horribly disfigured man is worked on by Christian and Sean. Meanwhile, Sean hopes to strike up a relationship with the new anesthesiologist Teddy Rowe, and Christian goes for a check up with his oncologist.

While preparing for a big event, Lizzie has a clash with her mother, and Christian searches for a new surgeon for the practice. He chooses Dr. Logan Taper, who loves his new office. Meanwhile, a dying man insists his wife comes back and receives more plastic surgery from Sean, so she can attract the right kind of suitor after he's gone.

Sean does not know that the seductive Teddy has a double life as the nurse 'Dixie Collins' in Las Vegas and carrying on a tryst of her own with the sleazy Dr. Harlan Frank... who is also unaware of her double life in L.A... and that of her homicidal tendencies. Elsewhere, Christian and Sean deal with a self-proclaimed vampire couple who ask for surgery done to repair their scaring from their regular blood drinking.